ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)
Biotechnologia Acta Т. 19, No. 2, 2026
P. 5-15, Bibliography 55, Engl.
UDC: 606.61:615.014:615.456.3
doi: https://doi.org/10.15407/biotech19.02.005
EFFECTIVENESS OF LIPOSOMAL DRUG DELIVERY SYSTEMS FOR CREATING THERAPEUTIC FORMS OF QUERCETIN
D. М. Pylypenko1, G. S. Grigoryeva 2, Yu. М. Krasnopolsky 3
1 State Biotechnological University, Ukraine
2 State Institution “Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine”
3 National Technical University "Kharkiv Polytechnic Institute", Ukraine
Quercetin is a well-known natural antioxidant with a wide spectrum of pharmacological activities, including in oncology, cardiology, ophthalmology, and other areas. Quercetin's lipophilic nature limits its clinical use and necessitates the development of effective delivery systems. Liposomal forms of quercetin are being actively studied and improved.
Aim. The article analyzes modern research on liposomal formulations of quercetin as a promising drug-delivery strategy.
Materials and methods. Analysis of modern national and foreign research on the creation of liposomal forms of quercetin and the evaluation of the efficacy of this drug delivery system in the treatment of oncological, cardiological, viral, and other diseases accompanied by oxidative stress. To search for sources of information for the study, open-access electronic resources of scientific periodicals were used.
Results. The development of liposomal quercetin formulations enabled increased bioavailability and expanded administration options, including injection. The use of liposomal quercetin in complex cancer therapy increased tumor growth inhibition while reducing side effects in healthy tissues. To improve the efficacy of quercetin delivery to tissues, it was proposed to modify liposome surfaces with hyaluronic acid, mycophenolic acid, polyethylene glycol, and magnetic particles. The possibility of using other carriers for quercetin delivery was demonstrated, including solid lipid nanoparticles, gold nanoparticles, and polymers.
Conclusions. Quercetin nanopreparations demonstrate high pharmacological efficacy and a significant increase in quercetin bioavailability, and their safety, biodegradability, and reduced toxicity are also important.
Keywords: quercetin, antioxidant, anticancer therapy, dosage form, drug delivery system, nanoparticle, liposome, bioavailability.
D. М. Pylypenko, https://orcid.org/0000-0002-4727-0476
G. Grigoryeva, https://orcid.org/0009-0009-5079-4295
Yu. М. Krasnopolsky, https://orcid.org/0000-0003-3469-5827
© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2026
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