RESISTANCE TO ANTIBIOTICS AND THEIR UTILIZATION BY MICROORGANISMS Golub N.B., Shi Xinhua , Levtun I.I.

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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

Biotechnologia Acta V. 14, No 3, 2021
Р.22-29, Bibliography 48 , English
Universal Decimal Classification: 57.047:57.022:57.043:57.044
https://doi.org/10.15407/biotech14.03.021

RESISTANCE TO ANTIBIOTICS AND THEIR UTILIZATION BY MICROORGANISMS

Golub N.B.¹, Shi Xinhua ², Levtun I.I.¹

¹National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ukraine
²Advanced Materials Institute of SDAS, China

With the development of antibiotics application, their spread in the natural environment increases dramatically. The presence of antibiotics in the environment changes microorganism and other living beings ratio and composition, which causes a negative impact on biochemical processes that take place in the environment. The spread of antibiotic resistance genes in environmental microorganisms is a growing problem of environmental safety and human health.

Aim. The objective of the work was to analyze the adaptation mechanisms of microorganisms to the influence of antibiotics and methods for antibiotics utilization.

Results. The mechanisms of microorganisms’ adaptation to antibiotics are shown. The conditions for utilization of different antibiotics classes by microorganisms are provided.

Conclusions. Methods of antibiotics destruction depend on its structure and physicochemical properties. Physico-chemical methods are used for local waste purification and are not suitable for antibiotics disposal in the natural environment. The decomposition products can also have a negative effect on the microorganisms’ cells.

Depending on the class of antibiotics, their biodegradation occurs by different types of microorganisms. It has been shown that sulfonamides and amphinecoles are easily destroyed by many heterotrophic bacteria; biodegradation of aminoglycosides occurs by a strain of Pseudomonas spp.; tetracyclines - mushrooms; β-lactams - through the microorganisms’ association including: Burkholderiales, Pseudomonadales, Enterobacteriales, Actinomycetales, Rhizobiales, Sphingobacteriales. A consortium of destructors must be created to dispose of a specific classes of antibiotics.

Key words: Antibiotics utilization; microorganisms resistance; tetracycline; norfloxancin; resistance factors.

References

1. Grenni P., Ancona V., Caracciolo A. B. Ecological effects of antibiotics on natural ecosystems: A review. Microchem. J. 2017. https://doi.org/10.1016/j.microc.2017.02.006

2. Ruicheng Wei, Tao He, Shengxin Zhang, Lei Zhu, Bin Shang, Zhaojun Li, Ran Wang. Occurrence of seventeen veterinary antibiotics and resistant bacterias in manure fertilized vegetable farm soil in four provinces of China. Chemosphere. 2018, V. 215, P. 234-240. https://doi.org/10.1016/j.chemosphere.2018.09.152

3. Houpu Zhang, Shiyu Chen. Fungicides enhanced the abundance of antibiotic resistance genes in greenhouse soil. Environ. Pollution. 2020, V. 259, P. 113877. https://doi.org/10.1016/j.envpol.2019.113877

4. Muhammad J., Khan S., Su J. Q., Hesham A. E.-L. Antibiotics in poultry manure and their associated health issues: a systematic review. J. Soils Sediments Springer. 2019, 1-12 p. https://doi.org/10.1007/s11368-019-02360-0

5. Checcucci A., Trevisi P., Luise D., Mattarelli P. Exploring the Animal Waste Resistome: The Spread of Antimicrobial Resistance Genes Through the Use of Livestock Manure, Frontiers in Microbiology. 2020, V. 11, P. 1-9. https://doi.org/10.3389/fmicb.2020.01416

6. Conde-Cid M., Ferreira-Coelho G. Adsorption/desorption of three tetracycline antibiotics on different soils in binary competitive systems. J. Environ. Management. 2020, V. 262, P. 110337. https://doi.org/10.1016/j.jenvman.2020.110337

7. Kobaa O., Golovko O. Antibiotics degradation in soil: A case of clindamycin, trimethoprim, sulfamethoxazole and their transformation products. Environ. Pollution. 2017, V. 220, P. 1251-1263. https://doi.org/10.1016/j.envpol.2016.11.007

8. Gothwal R., Shashidhar T. Antibiotic Pollution in the Environment: A Review. Clean-Soil Air Water. 2015, 43 (4), 463-620. https://doi.org/10.1002/clen.201300989

9. Xie W. Y., Shen Q. Antibiotics and antibiotic resistance from animal manures to soil: a review. Eur. J. Soil Sci. 2018, V. 69, P. 181-195. https://doi.org/10.1111/ejss.12494

10. Munir M., Xagoraraki I. Levels of Antibiotic Resistance Genes in Manure, Biosolids, and Fertilized Soil. J. Environ. Qual. 2011, V. 40, P. 248-255. https://doi.org/10.2134/jeq2010.0209

11. Lingxi Han, Lin Cai. Development of antibiotic resistance genes in soils with ten successive treatments of chlortetracycline and cipro?oxacin. Environ. Pollution. 2019, V. 253, P. 152-160. https://doi.org/10.1016/j.envpol.2019.07.031

12. Baquero F., Ana P. Tedim, Teresa M. Coque. Antibiotic resistance shaping multi-level population biology of bacteria. Front Microbiol. 2013, V. 4, P. 15. PMID: 23508522]. https://doi.org/10.3389/fmicb.2013.00015

13. D'Costa V. M., McGrann K. M., Hughes D. W., Wright G. D. Sampling the antibiotic resistome. Science. 2006, 311 (5759), 374-377. https://doi.org/10.1126/science.1120800

14. Munita J. M., Arias C. A. Mechanisms of Antibiotic Resistance. Microbiol. spectrum. 2016, 4 (2), 1128-1152. https://doi.org/10.1128/microbiolspec.VMBF-0016-2015

15. Li X. Z., Nikaido H. Efflux-Mediated Drug Resistance in Bacteria: an Update (англ.) // Drugs J. - Adis Inter. 2009, 69 (12), 1555-1623. PMID 19678712. https://doi.org/10.2165/11317030-000000000-00000

16. Aminov R. I., Mackie R. I. Evolution and ecology of antibiotic resistance genes. Microbiol. Letters. 2007, 271 (2), 147-161. https://doi.org/10.1111/j.1574-6968.2007.00757.x

17. Dzidic S., Suskovic J., Kos B. Antibiotic Resistance Mechanisms in Bacteria: мBiochemical and Genetic Aspects. Food Technol. Biotechnol. 2008, 46 (1), 11-21.

18. Blair J. M. A., Webber M. A., Baylay A. J., Ogbolu D. O., Piddock L. J. V. Molecular mechanisms of antibiotic resistance. Nat. Rev. Microbiol. 2014, V. 13, P. 42-51. https://doi.org/10.1038/nrmicro3380

19. Vargiu A. V., Pos K. M., Poole K., Nikaido H. Editorial: bad bugs in the XXIst century: resistance mediated by multi-drug efflux pumps in Gram-negative bacteria. Front. Microbiol. 2016, V. 7, P. 833-836. https://doi.org/10.3389/fmicb.2016.00833

20. Alekshun M. N., Levy S. B. The escherichia coli mar locus - antibiotic resistance and more. ASM News. 2004, V. 70, P. 451-456.

21. Wiese A., Brandenburg K., Ulmer A. J., Seydel U., M?ller-Loennies S. The dual role of lipopolysaccharide as effector and target molecule. Biol. Chem. 1999, V. 380, P. 767-784. https://doi.org/10.1515/BC.1999.097

22. Collin F., Karkare S., Maxwell A. Exploiting bacterial DNA gyrase as a drug target: current state and perspectives. Appl. Microbiol. Biotechnol. 2011, 92 (3), 479-497. https://doi.org/10.1007/s00253-011-3557-z

23. Monserrat-Martinez A., Gambin Y., Sierecki E. Thinking Outside the Bug: Molecular Targets and Strategies to Overcome Antibiotic Resistance. Int. J. Mol. Sci. 2019, 20 (6), 1-23. https://doi.org/10.3390/ijms20061255

24. Spratt B. G., Bowler L. D., Zhang Q. Y., Zhou J., Smith J. M. Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species. J. Mol. Evol. 1992, V. 34, P. 115-125. https://doi.org/10.1007/BF00182388

25. Bondarchuk Y. Antibiotic resistance: what solutions are offered by the world's largest organizations? 2018, № 8 (1129). https://www.apteka.ua/article/447433

26. Solliec M., Roy-Lachapelle A. Fractionation and analysis of veterinary antibiotics and their related degradation products in agricultural soils and drainage waters following swine manure amendment. Sci. Total Environ. 2016, V. 543, P. 524-535. https://doi.org/10.1016/j.scitotenv.2015.11.061

27. Zeyou Chen, Wei Zhang. Antibiotic resistance genes and bacterial communities in corn field and pasture soils receiving swine and dairy manures. Environ. Pollution. 2019, V. 248, P. 947-957. https://doi.org/10.1016/j.envpol.2019.02.093

28. Sun W., Qian X., Gu J., Wang X. J., Duan M. L. Mechanism and Effect of Temperature on Variations in Antibiotic Resistance Genes during Anaerobic Digestion of Dairy Manure. Sci. Rep. 2016, 6 (30237). https://doi.org/10.1038/srep30237

29. Hang Liu, Yongkui Yang. Fate of tetracycline in enhanced biological nutrient removal process. Chemosphere. 2018, V. 193, P. 998-1003. https://doi.org/10.1016/j.chemosphere.2017.11.136

30. Huijun Ding, Yixiao Wu. Simultaneous removal and degradation characteristics of sulfonamide, tetracycline, and quinolone antibiotics by laccase-mediated oxidation coupled with soil adsorption. J. Hazardous Materials. 2016, V. 307, P. 350-358. https://doi.org/10.1016/j.jhazmat.2015.12.062

31. Zhendong Zhao, Tiantian Nie, Wenjun Zhou. Enhanced biochar stabilities and adsorption properties for tetracycline by synthesizing silica-composited biochar. Environ. Pollution. 2019, V. 113015, P. 254-260. https://doi.org/10.1016/j.envpol.2019.113015

32. G?mez-Pacheco C. V., S?nchez-Polo M., Rivera-Utrilla J., L?pez-Pe?alver J. J. Tetracycline degradation in aqueous phase by ultraviolet radiation, Author links open overlay panel. Chem. Engin. J. 2012, V. 187, P. 89-95. https://doi.org/10.1016/j.cej.2012.01.096

33. Seong Ho Yun, Eun Hea Jho. Photodegradation of tetracycline and sulfathiazole individually and in mixtures. Food Chem. Toxicol. 2018, V. 116, P. 108-113. https://doi.org/10.1016/j.fct.2018.03.037

34. Mass? D. I., Saady N. M. C., Gilbert Y. Potential of biological processes to eliminate antibiotics in livestock manure: an overview. Animals. 2014, 4 (2), 146-163. https://doi.org/10.3390/ani4020146

35. Chu-Wen Yang, Chien Liu, Bea-Ven Chang. Biodegradation of Amoxicillin, Tetracyclines and Sulfonamides in Wastewater Sludge. Water. 2020, 12 (2147), 1-18. https://doi.org/10.3390/w12082147

36. Jianfei Chen, Shuguang Xie. Overview of sulfonamide biodegradation and the relevant pathways and microorganisms. Sci. Total Environ. 2018, V. 640, P. 1465-1477. https://doi.org/10.1016/j.scitotenv.2018.06.016

37. Bing Li, Tong Zhang. Biodegradation and Adsorption of Antibiotics in the Activated Sludge Process. Environ. Sci. Technol. 2010, V. 44, P. 3468-3473 https://doi.org/10.1021/es903490h

38. Mingeot-Leclercq M.-P., Glupczynski Y., Tulkens P. M. Antimicrob Agents Chemother. Aminoglycosides: Activity and Resistance. 1999, 43 (4), 727-737. https://doi.org/10.1128/AAC.43.4.727

39. Mitchell S. M., Ullman J. L., Teel A. L., Watts R. J. Hydrolysis of amphenicol and macrolide antibiotics: Chloramphenicol, florfenicol, spiramycin, and tylosin. Chemosphere. 2015, 08 (50), 134-140. https://doi.org/10.1016/j.chemosphere.2014.08.050

40. Xianghua Wen, Yannan Jia, Jiaxi Li. Degradation of Tetracycline and Oxytetracycline by Crude Lignin Peroxidase Prepared from Phanerochaete chrysosporium - A White Rot Fungus. Chemosphere. 2009, 75 (8), 1003-1007. https://doi.org/10.1016/j.chemosphere.2009.01.052

41. Batt A. L., Kim S., Aga D. S. Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations. Chemosphere. 2007, 68 (3), 428-435. https://doi.org/10.1016/j.chemosphere.2007.01.008

42. Kim S., Eichhorn P., Jensen J. N., Weber A. S., Aga D. S. Removal of antibiotics in wastewater: Effect of hydraulic and solid retention times on the fate of tetracycline in the activated sludge process. Environ. Sci. Technol. 2005, 39 (15), 5816-5823. https://doi.org/10.1021/es050006u

43. Forsberg K. J., Patel S., Wencewicz T. A., Dantas G. The tetracycline destructases: a novel family of tetracycline-inactivating enzymes. Chem. Biol. 2015, V. 22, P. 888-897. https://doi.org/10.1016/j.chembiol.2015.05.017

44. Dantas G., Sommer M. O. A., Oluwasegun R. D., Church G. M. Bacteria subsisting on antibiotics. Science. 2008, 320 (5872), 100-103. https://doi.org/10.1126/science.1155157

45. Drillia P., Dokianakis S. N., Fountoulakis M. S., Kornaros M., Stamatelatou K., Lyberatos G. On the occasional biodegradation of pharmaceuticals in the activated sludge process: The example of the antibiotic sulfamethoxazole. J. Hazard. Mater. 2005, 122 (3), 259-265. https://doi.org/10.1016/j.jhazmat.2005.03.009

46. Gartiser S., Elke U., Radka A., K?mmerer K. Ultimate biodegradation and elimination of antibiotics in inherent tests. Chemosphere. 2007, 67 (3), 604-613. https://doi.org/10.1016/j.chemosphere.2006.08.038

47. Wang Q.-Q., Bradford S. A., Zheng W., Yates S. R. Sulfadimethoxine Degradation Kinetics in Manure as Affected by Initial Concentration, Moisture, and Temperature. J. Environ. Qual. 2006, V. 35, P. 2162-2169. https://doi.org/10.2134/jeq2006.0178

48. Karthikeyan K. G., Meyer M. T. Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Sci. Total Environ. 2006, 361 (1-3), 196-207. https://doi.org/10.1016/j.scitotenv.2005.06.030