"Biotechnologia Acta" V. 10, No 3, 2017
https://doi.org/10.15407/biotech10.03.007
Р. 7-19, Bibliography 74, English
Universal Decimal Classification: (542.2:546.3-168):615.9
TOXIC EFFECTS OF NANOPARTICLES
Leonenko N. S., Leonenko O. B.
State Organization “Institute of Occupational Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv
The review summarizes the literature data on the assessment of the toxic effects of nanoscale particles at various concentrations and routes of entry into the body. The toxic effect of nanoobjects is more complex and diverse in comparison with the effect of traditional toxicants (heavy metals, organic solvents, poisonous substances, etc.). Despite the growing amount of data, there are no unified approaches to studying the toxic effects of nanoscale particles. This requires the development of specific procedures for their toxicity assessing.
Key words: nanoparticles, methods of toxic effect assessment.
References
- Chaudhry Q. Current and projected applications of nanomaterials. WHO Workshop on Nanotechnology and Human Health: Scientific Evidence and Risk Governance. Bonn, Germany, 10–11 December 2012.
- Prodanchuk N. G., Balan G. M. Nanotoxicology: State and Investigation Perspectives. Sovremennye problemy toksykologii. 2009, N 3‒4, P. 4‒20. (In Russian).
- Cao G., Van I. Nanostructures and Nanomaterials: Synthesis, Properties and Applications. Moskwa: Nauchnyj mir. 2012, 520 p. (In Russian).
- Erofeev N. P., Zegrja G. G., Vcherashnij D. B. Nanostructures: physical nature and applications in medicine. Uspekhi khimii. 2011, N 8, P. 48–53. (In Russian).
5. Pavlygo T. M., Serdjuk G. G., Pavlygo I. Ju. Danger nanomaterials and sandardized methods of its evaluation. Mizhvuzivs'kyj zbirnyk "NAUKOVI NOTATKY". Luck. 2015, Vypusk 49, P. 114–118. (In Ukrainian).
- Poland C. Nanoparticles: Possible routes of intake. WHO Workshop on Nanotechnology and Human Health: Scientific Evidence and Risk Governance. Bonn, Germany, 10–11 December 2012, 4–6.
7. Sahu S. C., Casciano D. A. Nanotoxicity: From In Vivo and In Vitro Models to Health Risks. Wiley. 2009, 630 p.
- Hartung T., Bremer S., Casati S., Coecke S., Corvi R., Fortaner S., Gribaldo L., Halder M., Roi A.J., Prieto P., Sabbioni E., Worth A., Zuang V. ECVAM's response to the changing political environment for alternatives: consequences of the European Union chemicals and cosmetics policies. Altern. Lab. Anim. 2003, 31 (5), 473–481.
- Ji J. H. Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague-Dawley rats. Inhal. Toxicol. 2007, 19 (10), 857–871.
- Guskova O. A. Zavjalov N. V., Skvorcova E. L. Nanoparticles of silver, titanium, zinc. Review of modern toxicological data. Sanitarnyj vrach. 2014, N 6, P. 47–52. (In Russian).
- Zaytseva N. V., Zemlyanova M. A., Zvezdin V. N., Dovbysh A. A., Gmoshinsky I. V., Khotimchenko S. A., Safenkova I. V., Akafyeva T. I. Toxicological assessment of nanostructured silica. The acute oral toxicity. Voprosy pitaniya. 2014, 83 (2), 42–49. (In Russian).
- 12. Chen Z., Meng H., Hing G. Acute toxicological affects of copper nanoparticles in vivo. Lett. 2006, V. 163, P. 109–120.
- 13. Mitrokhin N. M., Golubeva M. I., Razumnaya I. N., Fastov S. A., Fastov I. S. Experimental data on the toxicity and risk of aluminosilicate nanotubes. Toksikologicheskiy vestnik. 2016, N 2, P. 52–55. (In Russian).
- 14. Wang J., Zhou G., Chen C. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Phis. Chem. 2007, V. 168, P. 176–185.
15. Karkischenko N. N. Nanosafety: new approaches to estimation of risk and nanomaterials toxicity. Biomedicina. 2009, N 1, P. 5–27. (In Russian).
- 1 Dunford R., Salinaro A., Cai L. et al. Chemical Oxidation and DNA Damage Catalyzed by Inorganic Sunscreen Ingredients. FEBS Lett. 1997, 418 (1–2), 87–90.
17. Takeda K., Shinkai Y., Suzuki K., Suzuki K., Yanagita S., Umezawa M., Yokota S., Tainaka H., Oshio S., Ihara T., Sugamata M. Health effects of nanomaterials on next generation. Yakugaku Zasshi. 2011, 131 (2), 229–236.
18. Elder A., Gelein R., Silva V., Feikert T., Opanashuk L., Carter J., Potter R., Maynard A., Ito Y., Finkelstein J., Oberdörster G. Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System. Envir. Health Persp. 2006, 114 (8), 1172–1178.
19. Chen Z., Meng H. A., Xing G. M. Chen C., Zhao Y., Jia G., Wang T., Yuan H., Ye C., Zhao F., Chai Z., Zhu C., Fang X., Ma B., Wan L. Acute Toxicological Effects of Copper Nanoparticles in vivo. Toxicol. Lett. 2006, V. 163, P. 109–120.
- 20. Wang B., Feng W. Y., Wang T. C., Jia G., Wang M., Shi J. W., Zhang F., Zhao Y. L., Chai Z. F. Acute Toxicity of Nano- and Micro-scale Zinc Powder in Healthy Adult Mice. Lett. 2006, V. 161, P. 115–123.
- Zvezdin V. N., Zemlyanova M. A., Akafieva T. I. Inhalation toxicity of nanodispersed manganese oxide aerosol. Meditsina truda i promyshlennaya ekologiia. 2015, N 12, P. 13–16. (In Russian).
- Kim Y. S., Kim J. S., Cho H. S., Rha D. S., Kim J. M., Park J. D., Choi B. S., Lim R., Chang H. K., Chung Y. H., Kwon I. H., Jeong J., Han B. S., Yu I. J. Twenty-eightday oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal. Toxicol. 2008, 20 (6), 575–583.
- 23. Sung J. H., Ji J. H., Yoon J. U. Kim D. S., Song M. Y., Jeong J., Han B. S., Han J. H., Chung Y. H., Kim J., Kim T. S., Chang H. K., Lee E. J., Lee J. H., Yu I. J. Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles. Toxicol. 2008, 20 (6), 567–574.
- 24. Zahidov S. T. Nanotechnology and genetic safety. Sbornik tezisov i statej: Vserossijskaja nauchnaja shkola dlja molodezhi “Nanomedicina i nanotoksikologija”. Мoskva: МДВ. 2009, 32 p. (In Russian).
- 25. Oberdorster G., Oberdorster E., Oberdorster J. Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles. Health Perspect. 2005, 7 (113), 823–839.
- 26. Hardman R. A. Toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Health Perspective. 2006, 114 (2), 165–172.
- Kovalenko L. V., Folmanis G. E. Bioactive iron nanop. Мoskwa: Nauka. 2006, 124 p. (In Russian).
- Kuzmin S. V., Privalova L. I., Katsnelson B. A., Nikolayeva Ye. V., Degtyaryova T. D., Minigaliyeva I. A., Valamina I. Ye., Kireyeva Ye. P., Sutunkova M. P., Shur V. Ya., Yeryomenko O. S., Khodos M. Ya., Glazyrina Yu. A., Kozitsina A.N., Malakhova N. A., Shishkin Ye. I. Experimental data to assess the pulmonotoxicity and resorptive toxicity of magnetite (Fe3O4) particles in the nano- and micrometer range. Toksikologicheskiy vestnik. 2010, N 2, P. 17–24. (In Russian).
- Katsnelson B. A., Privalova L. I., Degtyaryova T. D., Kuzmin S. V., Gurvich V. B., Sutunkova M. P., Kireyeva Ye. P., Minigaliyeva I. A., Yeryomenko O. S. About the validation of the tentative safe exposure level of the metal-containing nanoparticles impact in occupational air. Toksikologicheskiy vestnik. 2012, N 4, P. 26–29. (In Russian).
30. Trakhtenberg I. M., Dmytrukha N. M. Nanoparticles of metals, methods of definition, spheres of use, physico-chemical and toxic properties. Ukrainskyj zhurnal z problem medycyny praci. 2013, 4 (37), 109–120. (In Ukrainian).
- 31. Gmoshinsky I. V., Khotimchenko S. A., Shipelin V. A. Trushina E. N., Mustafina D. C. Toxicological and hygienic assessment of the safety of nanomaterials used in food products. Nanotoksikologija: dostizhenija, problemy i perspektivy: materialy nauch. konf. Volgograd. 2014, P. 29–31. (In Russian).
- Shumakova A. A., Smirnova V. V., Tananova O. N., Trushina Je. N., Kravchenko L. V., Aksenov I. V., Selifanov A. V., Soto C. X., Kuznecova G. G., Bulahov A. V., Safenkova I. V., Gmoshinskij I. V., Hotimchenko S. A. Toxicological-hygienic characteristics of silver nanoparticles introduced into the gastrointestinal tract of rats. Voprosy pitanija. 2011, N 6, P. 9–18. (In Russian).
- Beljaeva N. N., Mihajlova R. I., Sycheva L. P., Savostikova O. N., Zelenkina E. A., Gasimova Z. M., Alekseeva A. V., Ryzhova I. N., Altaeva A. A. Assessing the impact of multi-walled carbon nanotubes on the morphofunctional cellular state of the small intestine in mice. Gigiena i sanitarija. 2012, N 6, P. 58–61. (In Russian).
- Beljaeva N. N., Sycheva L. P., Savostikova O. N. Structural and functional analysis of the six-month exposure of multilayer carbon nanotubes to the small intestine of rats. Bjulleten jeksperimentalnoj biologii i mediciny. 2016, N 6, P. 785–788. (In Russian).
- Shipelin V. A., Arianova E. A.,Trushina Je. N., Avreneva L. I., Batishheva S.Ju., Cherkashin A. V., Soto S. H., Lashnea N. V., Gmoshinskij I.V., Hotimchenko S. A. Toxicological and hygienic characteristics of fullerene C60 when it is introduced into the gastrointestinal tract of rats. Gigiena i sanitarija. 2012, N 2, P. 90–94. (In Russian).
- Khodykina N. V. Gorshenin A. V. Klauchek V. V., Pocheptsov A. Y., Sroslov M. S., Tochilkina L. P., Shalagina T. A., Filatov B. N. Experimental study of chronic oral toxicity of non-functionalized spherical silver nanoparticles. Nanotoksikologija: dostizhenija, problemy i perspektivy: materialy nauch. konf. Volgograd. 2014, P. 65–66. (In Russian).
- Beljaeva N. N.,Gasimova Z. M., Mihajlova R. I., Savostikova O. N., Alekseeva A. V. Morphofunctional cellular evaluation of the dynamics of the effect of silver nanoparticles on the liver of rats. Gigiena i sanitarija. 2014, N 1, P. 50–54. (In Russian).
38. Rippel R. A., Seifalian A. M. Gold revolution--gold nanoparticles for modern medicine and surgery. J. Nanosci. Nanotechnol. 2011, N 5, P. 3740–3748.
39. Romanko M. Je., Rjeznichenko L. S., Gruzina T. G., Dybkova S. M., Ul'berg Z. R., Ushkalov V. O., Golovko A. M. Influence of gold and silver nanoparticles on атрase activity of native and rehydrated cells of Escherichia coli. Ukr. biokhim. zh. 2009, 81 (6), 70–76. (In Ukrainian).
40. Bogoslovskaja O. A., Sizova E. A., Poljakova V. S., Miroshnikov S. A., Leipunsky I. O. Olkhovskaja I. P., Glushchenko N. N. Biological properties and methods of standardization NP copper. Nanotehnologii i nanomaterialy dlja biologii i mediciny: Sbornik materialov nauchno-prakticheskoj konferencii s mezhdunarodnym uchastiem: Novosibirsk. 2007, P. 177–181. (In Russian).
41. Bogoslovskaja O. A., Sizova E. A., Poljakova V. S., Miroshnikov S. A., Lejpunskij I. O., Olhovskaja I. P., Glushhenko N. N. The study of the safety of the introduction of copper nanoparticles with various physico-chemical characteristics in the animal organism. Vestnik Orenburgskogo gosudarstvennogo universiteta. 2009, N 2, P. 124–127. (In Russian).
42. Alidzhanova I. Je., Notova S. V, Kijaeva E. V. The influence of the stress factors of different nature on the accumulation of chemical elements in bodies of laboratory animals. Vestnik Orenburgskogo gosudarstvennogo universiteta. 2010, N 12, P. 18–21. (In Russian).
43. Sizova E. A, Miroshnikov S. A, Lebedev S. V, Glushchenko N. N. The effect of multiple introduction of copper nanoparticles on the elemental composition of the rat liver. Vestnik Orenburgskogo gosudarstvennogo universiteta. 2011, N 4, P. 104–110. (In Russian).
- Kucan A. T., Romanko M. E., Orobchenko A. L. Evaluation of safety and toxicity metalnanoparticlesas veterinarynanonutritsevtikaprototypes, to identify systematic biomarkers in experiments in vitro and in vivo. Materiály VIII mezinárodní vědecko-praktická konference “Moderní vymoženosti vědy – 2012”. Díl 22. Biologické vědy. Zvěrolékařství: Praha. Publishing House “Education and Science” s.r.o. S. 84–87. (In Russian).
45. Tochilkina L. P., Bocharova L. Ju., Sroslov M. S. Filatov B. N., Hodykina N. V. Embryotoxic effects of non-functionalized nanoparticles of gold and silver. Nanotoksikologija: dostizhenija, problemy i perspektivy: materialy nauch. konf. Volgograd. 2014, Р. 60–61. (In Russian).
46. Tochilkina L. P., Bocharova L. Ju., Sroslov M. S., Filatov B. N., Hodykina N. V. Experimental study of embryotoxicity of titanium nanooxide. Zh. “Medicina jekstremalnyh situacij”. 2014, 4 (50), 48–58. (In Russian).
- Gmoshinskij I. V., Hotimchenko S. A., Popov V. O., Dzantiev B. B., ZherdevA. V., Demin V. F., Buzulukov Ju. P. Nanomaterials and nanotechnologies: methods of analysis and control. Uspehi himii. 2013, 82 (1), 48–76. (In Russian).
- 48. Dykman L. A., Bogatyrev V. A., Shheglov S. Ju., Hlebcov N. G. Goldnanoparticles: synthesis, properties, Мoskwa: Nauka. 2008, 319 p. (In Russian).
- 49. Glushkova A. V., Radilov A. S., Rembovskij V. R. Nanotechnology and nanotoxicology – a view at the problem. Vestn. 2007, N 6, P. 4–8. (In Russian).
- Bocharova L. Ju., Tochilkina L. P., Hodykina N. V., Filatov B. N. Effect of nanoparticles of titanium dioxide and its macroanalog on the postnatal development of offspring. Toksikologicheskij vestnik. 2014, N 3, P. 26–32. (In Russian).
- Velikorodnaja Ju. I., Pochepcov A. Ja. Influence of nanoparticles of gold and silver on the reproductive function of male rats according to the immunohistochemical studies. Nanotoksikologija: dostizhenija, problemy i perspektivy : materialy nauch. konf. Volgograd. 2014, p. 28–30. (In Russian).
- Pochepcov A. Ja., Velikorodnaja Ju. I., Filatov B. N. Effect of gold nanoparticles on the proliferative activity of rat germ cells. Vestnik Volgogradskogo gosudarstvennogo Universiteta. 2012, 2 (42), 47–50. (In Russian).
- Kolesnikova I. S. Evaluation of the carcinogenic potential of the silica nanoparticles via lіmfotsitah alternative model in vitro Human peripheral blood. Nanotoksikologija: dostizhenija, problemy i perspektivy: materialy nauch. konf. Volgograd. 2014, P. 47–49. (In Russian).
54. Protasova G. A., Shabasheva L. V., Strekalovskij I. V., Panferova Yu. A., Kolesnikov I. S., Popov V. B. Integrated assessment of embryo-, cyto-, genotoxic and carcinogenic properties of nanoparticles in experiments in vitro. Nanotoksikologija: dostizhenija, problemy i perspektivy: materialy nauch. konf. Volgograd. 2014, P. 50–52. (In Russian).
- Durnev A. D. Estimation of genotoxicity of nanoparticles when used. Prophylactic toxicology and hygienic regulation. Gigiena i sanitarija. 2014, N 2, P.76–83. (In Russian).
- Shabasheva L. V., Protasova G. A., Strekalovskij I. V., Popov V. B. Experimental evaluation of cyto- and genotoxic/mutagenic effects roll dioxide nanoparticles in the culture of human peripheral blood lymphocytes. Nanotoksikologija: dostizhenija, problemy i perspektivy: materialy nauch. konf. Volgograd. 2014, P. 67–69. (In Russian).
57. Napierska D., Thomassen L. C., Lison D., Martens J. A., Hoet P. H. The nanosilica Hazard: another variable entity. Part. Fibre Toxicology. 2010, V. 7, P. 39.
- 58. Sahoo S. K., Parveen S., Panda J. J. The present and future of nanotechnology in human health care. : Nanotechnol. Biol. Med. . 2007, V. 3, P. 20–31.
- Dybkova S. M., Reznichenko L. S., Gruzina T. G., Ulberg Z. R. Evaluation of in vivo DNA-damaging action of gold nanoparticles of different sizes. Biotehnologija. 2010, 3 (3), 66–71. (In Ukrainian).
60. Stoccoro A., Karlsson H., Coppedè F. Genetic effect of nano-sized materials. Toxicology. 2013, N 7, P. 356–368.
61. Pfuhler S., Elespuru R., Aardema M., Doak S. H., Donner M. E., Honma M., Kirsch-Volders M., Landsiedel R., Manjanatha M., Singer T., Kim J. H. Genotoxicity of nanomaterials: refining strategies and tests for hazard identification. Environm. Mol. Mutagen. 2013, N 4, Р. 229–239.
62. Pan Y., Leifert A., Ruau D. Gold nanoparticles of diameter 1.4 nm trigger necrosis byoxidative stress and mitochondrial damage. Small. 2009, N 5, Р. 2067–2076.
- 63. Sulejmanova L. V. Morphological changes of the organs and tissues of experimental animals when exposed to gold nanoparticles. k. med. n. Saratov. 2009, 24 p. (In Russian).
- Masljakova G. N., Sulejmanova L. V., Gerenjuk T. S. Morphological changes in the internal organs of rats after intravenous administration of gold nanoparticles. Rossijskij bioterapevticheskij zh. 2009, 8 (1), 21. (In Russian).
65. Leonenko N. S., Demecka O. V. Express method for the determination of nanomaterials toxicity in in vitro solutions using cattle sperm as a test object. Ukraine. Pat. N 101308 UA; 09. 10. 2015. (In Ukrainian).
66. Leonenko N. S., Leonenko O. B., Demec'ka O. V., Tkachenko T. Ju., Grodzjuk G. Ja. Study of the cytotoxosity of CdS and PbS nanoparticles, stabilized with organic compounds. Suchasni problemy toksykolohii, harchovoi ta himichnoi bezpeky. 2015, N 3, P. 56–60. (In Ukrainian).
67. Syrma O. I. Physical properties of nanoparticles and their biological effects. Integratyvna Antropolohiya. 2013, 1 (21), 30–33. (In Ukrainian).
68. Larios-Rodriguez E., Rangel-Ayon A., Castillo S. J. Bio-synthesis of gold nanoparticles by human epithelial cells in vivo. Nanotechnology. 2011, 22 (35), 67–68.
69. Hubbs A. F., Sargent L. M., Porter D. W., Sager N. M., Chen B. T., Frazer D. G., Castranova V., Sriram K., Nurkiewicz T. R., Reynolds S. H., Battelli L. A., Schwegler-Berry D., McKinney W., Fluharty K. L., Mercer R. R. Nanotechnology: toxicologic pathology. Toxicol Pathol. 2013, 41 (2), 395–409.
- 70. Islamov R. A., Nersesjan A. K. Toxicological and pharmacological aspects of the study of nanomaterials and nanocomposites. nauch.-prakt. konf., posvjashh. 50-letiju Nauchno-issledovatel'skogo instituta problem biologicheskoj bezopasnosti: sb. materialov. Almaty. 2008, P. 128–130. (In Russian).
- Oberdorster G., Stone V., Donaldson K. Toxicology of nanoparticles: A historical perspective. Nanotoxicology. 2007, V. 1, Р. 2–25.
72. Demin V. F., Belushkina N. N., Palcev M. A. Health risk assessment from impact of nano-, nanobiomaterials:methods of evaluation and practical application. Molekuljarnaya medicina. 2012, N 4, P. 7–17. (In Russian).
73. Gao G., Ze Y., Zhao X. Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male mice. J. Hazard Mater. 2013, V. 15, P. 258–259.
74. Jiang W., Kim B. Y. S. Nanoparticles – mediated cellular response in size – dependent. Nanotechnology. 2008, V. 3, P. 145–150.
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