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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

"Biotechnologia Acta" v. 6, no. 2, 2013
 https://doi.org/10.15407/biotech6.02.034
Р. 33-42, Bibliography 73, English.
Universal Decimal classification: [620.22.532:549.282]:577.182.22(045)

SILVER NANOPARTICLES AS PENICILLIN ACTION ENHANCERS

O. A. Vasylchenko1 , V. V. Sologub1, K. K. Vasylchenko2

1National Aviation University, Institute of Ecological Safety, Kyiv
2Bogomolets National Medical University, Kyiv

Nowadays, the value of bactericidal nanomaterials research increases at the increasing number of bacteria strains resistant to the most highly potent antibiotics. In the review the characteristic of nanoparticles and methods for their production are done. The scope of nanoparticles application is observed, special attention is focused on silver nanoparticles usage in medicine, in particular, as bactericidal products. It is indicated that nanoparticles may have toxic effects.

Much attention is paid to nanoparticles application in the treatment of various diseases, for example, for targeted drug delivery, wound healing, bone regeneration, local heating of tumors in cancer pathology, immune system stimulation, for antibodies, viruses, bacteria detection, for liquids filtration.

Penicillins and their producers — Penicillium sp. characteristic is done. The mechanism of penicillin antimicrobial action is estimated.

It is revealed that silver nanoparticles usage in combination with antibiotics, particularly penicillin, leads to antibiotics antibacterial activity increasing against gram-positive and gram-negative microorganisms.

Key words: nanotechnology, silver nanoparticles, antibiotics, penicillin, Penicillium sp.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2013