ISSN 1995-5537
"Biotechnology" journal V. 4, No. 6, 2011
Р. 82-87, Bibliography 26, English.
Universal Decimal classification: 602.6:582.5/.9
COMPARATIVE STUDY OF ANTITUMOR EFFECT OF PRISTINE C60
FULLERENES AND DOXORUBICIN
S. V. Prylutska, А. P. Burlaka, Yu. I. Prylutskyy, U. Ritter, P. Scharff
Joint Ukrainian-German Center on Nanobiotechnology,
Kyiv National Taras Shevchenko University;
Kavetsky Institute of Experimental Pathology,
Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kyiv;
Technical University of Ilmenau, Institute of Chemistry and Biotechnology, Germany
The purpose of this study was mainly focused on the technology of application of C60 fullerenes in the combined therapy with doxorubicin for treatment of malignant tumors. Growth experiments of transplanted malignant tumors in the presence of pristine С60 fullerenes, doxorubicin and C60 in combination with doxorubicin were performed on groups of mice. It was found that C60 in combination with doxorubicin injection efficiently inhibits the growth of transplanted malignant tumor as well as metastases of Lewis lung carcinoma. The findings demonstrate the possibility of using C60 in combination with doxorubicin in anticancer therapy.
Key words: С60 fullerene; doxorubicin; Lewis lung carcinoma; tumor growth inhibition; increasing of animal life span; metastasis inhibition index.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008