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ISSN 1995-5537

2 2008

“Biotechnology” journal Vol. 1, No. 2, 2008
Р. 52-58, Bibliography 10, Ukrainian.
Universal Decimal classification 577.112.087:577.150.87:577.352.52 57:66:5773

Efficiency of immobilization of bovine leukaemia virus (BLV) antigen on the transducer surface of SPR biosensor by using of various agents (polyelectrolyte selfassembly, dodecantiol, dextran sulphate) was investigated. This technique was compared with direct immobilisation of the immune components on the bare gold. It was shown that modification of sensor surface with polyelectrolytes is most expedient and chip for screening of bovine leukosis.

Key words: bovine leucosis, bovine leukaemia virus, diagnostics, immune sensor analysis, surface plasmon resonance, dodecantiol, polyelectrolytes, dextran .

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008