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ISSN 2410-776X (Online),
ISSN 2410-7751 (Print)

 1 2015

"Biotechnologia Acta" v. 8, no 1, 2015;
Р. 82-87, Bibliography 43, English
Universal Decimal classification: 579.222: 547.979.8


A. G. Popandopulo1, M. V. Savchuk1, D. L. Yudickiy2

1SI « Husak Institute of Urgent and Recovery Surgery», Donetsk, Ukraine
2Gorky Donetsk National Medical University, Donetsk, Ukraine

Nowadays, definitive treatment for the end-stage organ failure is transplantation. Tissue engineering is an up to date solution to create the effective substitute of the defective organ. It involves the reconstitution of viable tissue with the use of autologous cells grown on connective tissue matrix, which has been acellularized before. Basis for the prothesis should be morphologically and physically nonmodified, so in case of making vessel-valvular biological prosthesises the decellularized extracellular matrix is the best variant. The xenogeneic extracellular matrix is economically and ethically more useful. The possibility of preservation of the morphological and chemical properties of matrix structure initiates the process of programmed cell death. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis doesn’t cause the tissue damages. One of the ways of realizing the apoptosis is the usage of EDTA — chelate, which binds the Ca2+ ions.

Key words: tissue engineering, extracellular matrix, decellularization, apoptosis, chelate.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2015