ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)
Biotechnologia Acta Т. 16, No. 6 , 2023
P. 34-47, Bibliography 70, Engl.
UDC:: 615.322: 578.76
DOI: https://doi.org/10.15407/biotech16.06.034
MECHANISMS OF ANTIVIRAL ACTIVITY OF FLAVONOIDS
Golembiovska O.I., Bespalova O.Ya.,Prosvetova A.B., Samsonenko S.M., Poyedynok N.L.
National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Ukraine
The article examines the multifaceted mechanisms underlying the antiviral activity of flavonoids, compounds widely distributed in the plant kingdom.
The aim of the work was to review literature data on mechanisms of antiviral activity of flavonoids.
Methods. Publications were selected based on the PubMed (https://pubmed.ncbi.nlm.nih.gov/) databases published in 2015–2023. They include information on mechanisms of antiviral activity of flavonoids.
Results. Beginning with an overview of flavonoid structures, the document navigates through the intricate interactions between flavonoids and various stages of the viral life cycle. Drawing upon a comprehensive analysis of in vitro and in vivo studies, the review highlights the diverse ways in which flavonoids inhibit viral entry, replication, and release. Depending on their antiviral mechanisms, flavonoids can serve as preventive inhibitors, therapeutic inhibitors, or indirect inhibitors by influencing the immune system.
Conclusion. The synthesized information not only contributes to the advancement of antiviral research but also lays the foundation for the development of novel therapeutic interventions against a spectrum of viral infections.
Key words: flavonoids, antiviral activity, viral infection, bioactive compounds, host-pathogen interaction.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2023
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