IMPACT OF Pleurotus tuber-regium (Rumph. ex Fr.) EXTRACT-LOADED NANOPARTICLES ON THYROID PROFILE OF RATS Sukumar Dandapat, Manoj Kumar, Rohit Srivastava, Manoranjan Prasad Sinha

Details: Category: 3_2021(en); Hits: 231

ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

3 2021 200ps

Biotechnologia Acta V. 14, No 3, 2021
Р. 62-66-, Bibliography 21, English
Universal Decimal Classification: 631.577
https://doi.org/10.15407/biotech14.03.062

IMPACT OF Pleurotus tuber-regium (Rumph. ex Fr.) EXTRACT-LOADED NANOPARTICLES ON THYROID PROFILE OF RATS

Sukumar Dandapat¹, Manoj Kumar², Rohit Srivastava¹, Manoranjan Prasad Sinha¹

¹ Department of Zoology, Ranchi University, Ranchi-834008, Jharkhand, India
² Department of Zoology, St. Xavier's College, Ranchi-834001, Jharkhand, India

Aim. The aim of this study was to investigate the impact of Pleurotus tuber-regium extract loaded silver nanoparticles (SNPs) on thyroid profile of rats.

Methods. Acute toxicity test was performed following up and down procedure and the analysis of thyroid profile was performed following chemiluminescence assay method.

Results. Acute toxicity test showed no mortality and no behavioral changes in rats treated with 2000 mg kg^-1 of SNPs. High dose (400 mg kg^-1) of SNPs showed high hyper thyroid activity by increasing T3 = 38.20±4.06 ng dL^-1; T4 = 4.40±0.32µg dL^-1; and by decreasing TSH = 0.73±0.06µIU mL^-1 compared to control group (T3 = 30.20±1.02 ng dL^-1; T4 = 2.94±0.08µg dL^-1; TSH = 0.87±0.01µIU mL^-1) and animal group treated with 200 mg kg^-1 dose of SNPs (T3 = 35.69±1.13 ng dL^-1; T4 = 3.82±0.24µg dL^-1; TSH = 0.80±0.02µIU mL^-1).

Conclusions. Pleurous tuber-regium extract loaded silver nanoparticles are non toxic and can be used in drug delivery as well as in the formulation of drugs used in hypothyroidism.

Key words: Pleurotus tuber-regium, silver nanoparticles, thyroid profile

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