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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

5 2017 cover
"Biotechnologia Acta" V. 10, No 5, 2017
Р. 43-50, Bibliography 13, English
Universal Decimal Classification: 577.113.6:602.643:54-126


N. U. Susol, D. D.Ostapiv, V. V.Vlizlo

Institute of Animal Biology of National Academy of Agrarian Sciences of  Ukraine,  Lviv

The aim of the research was to investigate the ability of new complexes as specific single-stranded oligonucleotides ? ODN ? with   dimethylaminomethylmethacrylate ? DMAEM ? based polymer carriers to inhibit the expression of the physiological prion. It has been established that the introduction of complexes of newly synthesized carriers based on dimethylaminomethyl methacrylate - PEG-DMAEM-MP-27 (magnetic particles) (MP-27), PEG- DMAEM-MP-2 (MP-2), PEG- DMAEM-MP-3 (MP-3)  with as ODH into the organism of rats leads to a decrease in the physiological prion content in the tissues of the spleen and small intestine. The influence of complexes of newly synthesized carriers  MP-27, MP-2 and MP-3 with as specific single-stranded oligonucleotides ODH on hematological and biochemical blood parameters of  Wistar rats was also studied.

Key words: prion infections, antisense-oligonucleotides, polymeric carriers.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2017