ISSN 1995-5537
"Biotechnology" journal V. 5, No. 3, 2012
Р. 9-17, Bibliography 75, Ukrainian.
Universal Decimal classification: 546.26.043
FULLERENE C60 AND ITS DERIVATIVES AS ANTICANCER AGENTS:
PROBLEMS AND PROSPECTS
S. V. Prylutska, Yu. M. Kichmarenko, K. I. Bogutska, Yu. I. Prylutskyy
Taras Shevchenko National University of Kyiv
Creation of new biocompatible materials, which can exhibit antitumor activity or enhance it in combination with conventional drugs, reducing their harmful side effects, is an important complex problem that requires the use of last accomplishments of biotechnology.
The data regarding the main physico-chemical properties and bioavailability of fullerene C60 and its derivatives, their membranotropic, toxic and tumortropic effects in vitro and in vivo systems are summarized in the review. Based on these generalizations the prospects of these unique nanostructures in oncology, particularly in the treatment of cancer patients and for diagnostic purposes are analyzed. At the same time, some problems arising from the use of fullerene С60 and its derivatives in medicine are highlighted. They are particularly associated with the creation of highly stable water-soluble non-toxic compounds of fullerene С60, which could be introduced into the human body and delivered with the bloodstream in the organ to be a therapeutic effect and their participation in the processes of metabolism.
Key words: fullerene C60 and its derivatives, bioavailability, toxicity, membranotropic and tumortropic effects.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008