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ISSN 1995-5537

"Biotechnology" journal V. 5, No. 2, 2012
Р. 31-40, Bibliography 36, Ukrainian.
Universal Decimal classification: 577.217


 V. V. Hurmach, A. M. Balynskyi, M. O. Platonov, P. O. Borysko, Yu. I. Prylutskyy

Kyiv National Taras Shevchenko University, Kyiv

The creation of new pharmaceuticals for treating diseases associated with impaired functioning of protein complexes is an important medical and social problem that requires a comprehensive approach to its solution, including consideration of recent advances in computer modeling of biological processes.

The text summarizes literature data about structure, functioning, classification, molecular disturbances of SH2 domains (Src Homology) and also provides description of the method of molecular docking as one of the most promising methods for pharmacological studies. It is shown that SH2-domains are of the most interest in terms of practical applications for new patentable inhibitor protein — protein interactions using molecular docking, because they are actively involved in intracellular signal transmission acting as mediators of specific interactions.

Key words: protein complexes, SH2-domains, molecular docking.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008