ISSN 1995-5537

"Biotechnology" journal V. 4, No. 5, 2011
Р. 64-70, Bibliography 21, Russian.
Universal Decimal classification: 546.26.043 + 544.77

PREPARATION AND BIOLOGICAL ACTIVITY OF AQUEOUS COLLOID SOLUTIONS
OF С₆₀ AND С₇₀ FULLERENE MIXTURES

I. E. Serdiuk, I. V. Belochkina, A. P. Kryshtal, А. D. Roshal, I. M. Neklyudov,
B. V. Borts, V. N. Voevodin, V. I. Tkachenko, B. P. Sandomirsky

Institute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of Ukraine, Kharkiv;
Karazin’s Kharkіv National University;
National Science Center «Kharkiv Institute of Physics and Technology» of National Academy of Sciences of Ukraine

There is information about fullerenes biological activity and their toxicity, although in most works the toxicity of the unmodified substances is exposed to the doubt.

The preparation of colloid solutions of С₆₀ and С₇₀ fullerene mixture, as well as the chemical composition and properties of the resulted sols are described. It has been found that the ratio of fullerenes С₆₀ and С₇₀ does not change on going from a solid phase into colloid solution. It has been shown that the obtained sols are resistant for water bath boiling and UV irradiation procedures. It has been also found that the properties of colloid solutions (micelle size and ability to aggregation) depend on their preparation conditions, in particular, on the time between preparing intermediate toluene solution of fullerenes and transfer of them into colloid solution. The studies have shown that colloid solutions of fullerenes possess substantial antioxidant properties, at the same time they do not possess any noticeable cytotoxic or antiproliferative effect on cell culture.

Key words: fullerenes, colloid solutions, biological and antioxidant activities.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008