ISSN 1995-5537

"Biotechnology" journal V. 4, No. 5, 2011
Р. 9-24, Bibliography 59, Ukrainian.
Universal Decimal classification: 546.26.043

CARBON NANOTUBES AS NEW MATERIALS FOR NEUROENGINEERING

D. M. Rotko,  S. V. Prylutska, K. I. Bogutska, Yu. I. Prylutskyy

Taras Shevchenko Kiyv National University

Creation of the newest biocompatible structures for interaction with nervous tissue is an important complex problem, which can’t be decided with the use of traditional technologies. For its decision, drawing on the last accomplishments of biotechnology is needed.

The data on the structure, chemical functionalization, electrical and mechanical properties of carbon nanotubes, which enable their practical use in neural engineering, in particular as efficient substrates for growth of neurons, neuroprotectors synthesis and as ion channel blockers are summarized in the review. In particular, it is shown that singlewalled carbon nanotubesinduce an increased growth of neurons  shoot; neuron growth on a substrate with multiwalled carbon nanotubes is accompanied by an increase of inter-network activity; single-walled carbon nanotubes block potential controlled potassium channels, stabilizing their conformation in the inactivated state after its induction. The action of amino-modified single-alled carbon nanotubes activates protective functions of the nervous tissue with respect to ischemic injury and reduces myocardium infarct area caused by by occlusion of middle cerebral artery of rats.

Key words: fluorescence, clusters of atoms of silver, sensory technologies.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008