ISSN 1995-5537
"Biotechnology" journal Vol. 4, No. 1, 2011
Р. 41-59, Bibliography 105, Ukrainian.
Universal Decimal Classification: 577.115.7:842.1/2
R. V. Grytsay, L. D. Varbanets
Zabolotny Institute of Microbiology and Virology of National Academy of Sciences of Ukraine, Kyiv
The data on peculiarities of lipopolysaccharide composition of gram-negative bacteria, including O-specific polysaccharide, oligosaccharide core and lipid A that are varied both composition and different degree of conservatism are shown in the survey. The ways of lipopolysaccharide molecule biosynthesis are considered. The ability of lipopolysaccharides to induce production of cytokines are shown. The receptors and proteins binding lipopolysaccharides with macroorganisms cells are described. So far as lipopolysaccharides are the main antigens of gram-negative bacteria, great deal of attention devoted to the antigenic properties of lipopolysaccharide molecule and its structural components. Their use in biotechnology is discussed.
Кey words: lipopolysaccharide, О-specific polysaccharide, oligosaccharide core, lipid A, biosynthesis, antigenic activity, use in biotechnology.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008