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ISSN 1995-5537

Cover 4 2010

"Biotechnology" journal Vol. 3, No. 4, 201
Р. 9-19, Bibliography 47, Ukrainian.
Universal Decimal classification: 577.322:577.332


G. P. Volynets, V. G. Bdzhola, S. M. Yarmoluk

Institute of Molecular Biology and Genetics
of the National Academy of Sciences of Ukraine, Kyiv

The most widespread methods of computer modeling in biology is given in the review. Protein sequence and structure alignments assist in detection of functional/evolutionary relationship. Molecular docking algorithms are powerful tools for rational drug design. Protein-protein docking may be used to predict the intermolecular complexes structure. The integration of computational tools with experimental approaches allows to reduce significantly the research cost.

Key words: amino acids sequence alignment, protein structure alignment, functional site, molecular docking.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008