ISSN 1995-5537

"Biotechnology" journal Vol. 3, No. 3, 2010
Р. 9-22, Bibliography 51, Ukrainian.
Universal Decimal classification: 616-77:616.13-089

BIOTECHNOLOGICAL ASPECTS
FOR CREATION OF ARTERIES TRANSPLANTS

Byzov D. V., Synchykova O. P., Pushkova E. М., Mikhailova I. P. Sandomirsky B. P.

Institute for Problems of Cryobiology and Cryomedicine
of National Academy of Sciences of Ukraine, Kharkіv

There is constantly growing need in vessel’s substitutes, since the number of cardiovascular diseases rises firmly and the age of the patients reduces steadily. To recreate the arteries of large diameter such as aorta, iliac arteries, the synthetic vascular prostheses based on PTFE, ePTFE in different modifications have been successfully used. However with the decrease in diameter of a vessel the percentage of functionally adequate blood flux reduces sharply when using the synthetic prostheses. The perspective trend is the creation of bioengineered arterial prostheses based on vascular scaffolds. The review covers the data on the creation of vascular substitutes, including those used during prosthetic repair of the vessels of small and average diameters.

Key words: bioengineering, vascular prosthesis, scaffolds, devitalization.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008