ISSN 1995-5537
“Biotechnology” journal Vol. 1, No. 1, 2008
P. 86-99, Bibliography. 18, English
Universal Decimal classification: 541.64:541.182:541.183
O. Zaichenko, R. Stoika, N. Mitina, M. Lutsik, O. Shevchuk, V. Lobaz, N.Boiko
Lviv Polytechnic National University, Ukraine
Institute of Cell Biology of National Academy of Sciences of Ukraine, Lviv
Principal experimental approaches based on tailored synthesis of oligoperoxide surface-active substances and their application for obtaining polymeric and hybrid nanoscale carriers possessing targeted functionality and biocompatibility are presented. Molecular design of novel linear, block and comb-like oligoperoxide surfactants and derived coordinating complexes of transitional and rare earth metal cations is a convenient tool for synthesis of luminescent, magnetic and other functional nanocomposites with controlled size distribution, functionality, reactivity and biocompatibility. The methods developed provide combining the stage of formation of polymeric, metal and metal-oxide nanoparticles with the stage of their surface irreversible modification by functional surface-active oligoperoxides capable of binding physiologically active substances. The availability of reactive ditertiary peroxide fragments provides a possibility for functionalization of developed nanoparticles that were applied for studying phagocytosis, surface markers of pathological cells, and targeted delivery of drugs and antimicrobial remedies.
Key words: oligoperoxide surfactants, metal complexes, radical emulsion polymerization, homogeneous nucleation, functional colloidal particles, «core-shell» polymerization, phagocytosis, drug delivery.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008