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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

cover biotech acta general

Biotechnologia Acta Т. 18, No. 3, 2025
P.  7-13, Bibliography 19 , Engl.
UDC 616-097:616-008.6:612.017.1:577.27
doi: https://doi.org/10.15407/biotech18.03.007

Full text: (PDF, in English)

DYSFUNCTION OF IMMUNE RESPONSE REGULATION AS A FUNDAMENTAL CAUSE OF AUTOIMMUNITY ONSET

A. Havrylyuk, I. Kril , M. Lomikovska , V. Chopyak

Danylo Halytsky Lviv National Medical University

Aim: To investigate the types of immune response regulation and immunological tolerance disorders in autoimmune diseases.

Methods: Bibliometric indicators` analysis of scientific articles and analytical materials from databases such as Scopus, Web of Science, DOAJ, and PubMed were used.

Results. The most important types of regulation of the immune response, which are disturbed in autoimmune diseases, are the withdrawal of immunological tolerance to self-antigens (in which cellular and cytokine types of regulation become unbalanced) and genetic type. It analyzed the consequences of dysregulation of cellular, cytokine, genetic, idiotypic-anti-idiotypic, and immune-neuroendocrine types, which cause a breakage of immunological tolerance and the start of autoaggression.

Conclusions. The consequences of dysregulation of the immune response, which causes the reversal of immunological tolerance, create the ground on which numerous autoimmune reactions quickly form into an autoimmune syndrome and become autoimmune diseases.

Keywords: immune response, immunological tolerance, Tregs, autoreactive B cells, apoptotic cells.

© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2025

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  1. Clinical Immunology and Allergology (scientific editorship of Valentyna Chopiak, Anna Gavrylyuk). Kyiv: Publishing house “Medytsyna”. 2025, 479. (in Ukrainian)
  2. Chopiak, V.V., Havryliuk, A.M. (2021). Potomkina H.O. Cellular and molecular immunology. Lviv, Publishing house “NeoDruk”. 162. (in Ukrainian)
  3. Chopiak, V.V., Potomkina, H.O., Havryliuk, A.M. (2010). Lectures on clinical immunology for practicing physicians (lecture series – part 1.). Lviv; Danyla Halytskii Publishing house LNMU. 226. (in Ukrainian)
  4. Golab, J., Jakobisiak, M., Lasek, W., Stoklosa, T. (2017). Immunologia (new edition). Warszawa:Wydawnictwo naukowe PWN SA, 497.
  5. Takakubo, Y., & Konttinen, Y. T. (2012). Immune-regulatory mechanisms in systemic autoimmune and rheumatic diseases. Clinical & developmental immunology, 2012, 941346. https://doi.org/10.1155/2012/941346
  6. Chopiak V.V., Havryliuk A.M., Tolstiak Ya.F., Kril I.I. (2020). Modern transplantology: immunodiagnostics and immunotherapy.. Lviv, Publishing house “NeoDruk”. 122. (in Ukrainian)
  7. Prajzlerová, K., Šenolt, L., Filková, M. (2022). Is there a potential of circulating miRNAs as biomarkers in rheumatic diseases?. Genes & diseases, 10(4), 1263–1278. https://doi.org/10.1016/j.gendis.2022.08.011
  8. Hampe C. S. (2012). Protective role of anti-idiotypic antibodies in autoimmunity--lessons for type 1 diabetes. Autoimmunity, 45(4), 320–331. https://doi.org/10.3109/08916934.2012.659299
  9. Hossen, M. M., Ma, Y., Yin, Z., Xia, Y., Du, J., Huang, J. Y., Huang, J. J., Zou, L., Ye, Z., Huang, Z. (2023). Current understanding of CTLA-4: from mechanism to autoimmune diseases. Frontiers in immunology, 14, 1198365. https://doi.org/10.3389/fimmu.2023.1198365
  10. Konig M. F. (2020). The microbiome in autoimmune rheumatic disease. Best practice & research. Clinical rheumatology, 34(1), 101473. https://doi.org/10.1016/j.berh.2019.101473
  11. Lee, B. W., Kwok, S. K. (2023). Mesenchymal Stem/Stromal Cell-Based Therapies in Systemic Rheumatic Disease: From Challenges to New Approaches for Overcoming Restrictions. International journal of molecular sciences, 24(12), 10161. https://doi.org/10.3390/ijms241210161
  12. Zefferino, R., Di Gioia, S., Conese, M. (2021). Molecular links between endocrine, nervous and immune system during chronic stress. Brain and behavior, 11(2), e01960. https://doi.org/10.1002/brb3.1960
  13. Lutshumba, J., Nikolajczyk, B. S., Bachstetter, A. D. (2021). Dysregulation of Systemic Immunity in Aging and Dementia. Frontiers in cellular neuroscience, 15, 652111. https://doi.org/10.3389/fncel.2021.652111
  14. Manley, K., Han, W., Zelin, G., Lawrence, D.A. (2018). Crosstalk between the immune, endocrine, and nervous systems in immunotoxicology. Current Opinion in Toxicology, 10, 37–45. https://doi.org/10/1016/j.cotox.2017.12.003
  15. Carvalho,F, Rodrigues, F.A. (2022). Activation of the neuro-immuno-endocrine system for pain treatment. Int J Health Sci. 2(44), 1–11. https://doi.org/10.22533/at.ed.1592442202088

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