PROSPECTS FOR THE USE OF UMBILICAL CORD BLOOD IN THE TREATMENT OF DISEASES OF THE CARDIOVASCULAR SYSTEM Shchenyavskyi I.Y.

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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

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Biotechnologia Acta Т. 16, No. 4, 2023
P. 30-42, Bibliography 83, Engl.
UDC: [578.8:57.083]:606
DOI: https://doi.org/10.15407/biotech16.04.031

Full text: (PDF in English)

PROSPECTS FOR THE USE OF UMBILICAL CORD BLOOD IN THE TREATMENT OF DISEASES OF THE CARDIOVASCULAR SYSTEM

Shchenyavskyi I.Y.

Institute of Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Cardiovascular diseases are currently the most common cause of death worldwide. In this regard, experimental and clinical studies of the effectiveness of therapy for ischemic and non-ischemic heart diseases using stem cells are relevant.

The purpose of this review was to evaluate the prospects of using cord blood stem cells in the treatment of cardiovascular diseases.

Methods. The following databases were searched: «BIGG International Database of GRADE guidelines», “Database of GRADE EtD's and Guidelines”, “Dynamed”, “ebmafrica.net”, “ECRI”, “MAGIC authoring and publication platform (MAGICapp)”, “National Health and Medical Research Council (NHMRC) portal”, “NICE Evidence”, “Pubmed”, “TRIP database”, “U.S. Preventive Services Task Force”.

Results. An analysis of research related to this problem, which was conducted in recent years, was made, and considerations regarding the prospects of using umbilical cord blood in the treatment of diseases of the cardiovascular system were outlined.

Conclusions. Despite some successes, realizing the full potential of cord blood stem cells in the treatment of cardiovascular diseases still requires further severe, targeted, and well-funded research and expanded clinical trials.

Key words: cardiovascular diseases, umbilical cord blood, stem cells.

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