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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)


Biotechnologia Acta V. 13, No 5, 2020
Р. 42-61, Bibliography 122, English
Universal Decimal Classification: 547.982


A. K. Gulevsky, I. I. Shcheniavsky

Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

This review presents the current scientific literature data about structure, properties, and functions of collagen, which is known as one of the most abundant human and animal proteins. The building of collagen molecule from the primary structure to submolecular formations, the main stages of its synthesis and biodegradation are briefly described. The information about collagen diversity, its features and metabolic ways in various tissues, including skin, tendons, bones, etc. is presented. The problems of pathologies caused by collagen synthesis and breakdown disorders as well as age-related changes in collagen properties and their causes are discussed.

A comparative analysis of the advantages and disadvantages of collagen and its derivatives obtaining from various sources (animals, marine, and recombinant) is given. The most productive methods for collagen extraction from various tissues are shown. The concept of collagen hydrolysis conditions influence on the physicochemical properties and biological activity of the obtained products is described.

The applications of collagen and its products in various fields of industrial activity, such as pharmaceutical, cosmetic industry and medicine, are discussed. Further prospective directions of fundamental and applied investigations in this area of research are outlined.

Key words: collagen types, collagen metabolism, sources of collagen production, collagen hydrolysis, application of collagen.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2020