Select your language

ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

 2 2015

"Biotechnologia Acta" V. 8, No 2, 2015;
Р. 107-111, Bibliography 16, Ukrainian
Universal Decimal classification: 546.26.043


Yu. I. Prylutskyy1, М. А. Zabolotnyy1, G. I. Solyanyk2, L. M. Kirkilevskaya2

1Taras Shevchenko National University of Kyiv, Ukraine
2Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, Kyiv
3National Medical University of the National Academy of Medical Sciences of Ukraine, Kyiv

Literature data and the results of the authors regarding the immobilization of traditional anticancer drugs on nanoparticles (e.g., by use of non-covalent binding, physical adsorption) with the aim of the targeted delivery of these anticancer agents and enhance their therapeutic actions have been analyzed. The physical aspects of these particles (e.g., size effect, specific surface energy), which should be taken into account for achieving their biocompatibility with the cells and tissues of the body have been discussed. It was indicated that irradiation of different nature (e.g., light, low energy electrons) can also be used to transfer molecules of medicals into a metastable state with their subsequent conversion into a state with increased pharmacological activity in immobilization on nanoparticles.

Key words: anticancer drugs, nanoparticles, immobilization.

© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2015