ISSN 1995-5537
"Biotechnology" journal V. 5, No.1, 2012
Р. 48-52, Bibliography 14, Ukrainian.
Universal Decimal classification: 573.3
CARBON NANOTUBES AS THE MODULATORS OF SPONTANEOUS
CONTRACTING ACTIVITY OF INTESTINAL SMOOTH MUSCLES
ESC «Institute of Biology», Kyiv National Taras Shevchenko University
Bogomolets National Medical University, Kiyv
Institute of Physics of National Academy of Sciences of Ukraine, Kiyv
By use the tensometrical method in the isometric condition on the isolated caecum smooth muscle strips it is shown that their spontaneous contracting activity is characterized by the amplitude distribution of contractions on the frequencies. It is established that in the presence of multi-walled carbon nanotubes in the dilutions of 1:1000, 1:100 and 1:50 in the normal Krebs solution the narrowing of the amplitude range of mooth muscle strips spontaneous contractions, their displacement in the region of large values for amplitude-frequency maximum, and also decreasing of generation frequency for the 1:100 and 1:50 dilutions take place. The washing of muscular preparations in normal Krebs solution expands the amplitude range of contractions, removes, caused by multi-walled carbon nanotubes in the dilutions of 1:1000 and 1:100, the shift and strengthening of amplitude-frequency maximum smooth muscle contractions, but does not ensure the restoration of the control profile for the amplitude distribution of contractions on the frequencies, except the case of presence multi-walled carbon nanotubes in normal Krebs solution in dilution of 1:1000. The changes in the spontaneous contracting activity of smooth muscle strips, caused by multi-walled carbon nanotubes in a dilution of 1:50, are not irreversible.
Key words: multi-walled carbon nanotubes, smooth muscles, spontaneous contractions.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008