ISSN 1995-5537
"Biotechnology" journal V. 4, No. 2, 2011
Р. 9-23, Bibliography 92, Russian.
Universal Decimal classification: 544.773.432:615.272+66.095.26
POLYMERIC SYSTEMS WITH CONTROLLED RELEASE
OF BIOACTIVE COMPOUNDS
Palladian Institute of Biochemistry of National Academy of Sciences of Ukraine, Kyiv
An analysis of polymeric systems with controlled release of bioactive compounds (BAC) including drugs, peptides, hormones, and proteins is provided in the overview. It is shown that matrices for such systems can be synthesized based on both natural (gelatin, polysaccharides, cellulose derivatives, chitosan, silk proteins,
etc.), and synthetic polymers (aliphatic polyesters, polymethacrylic acid, polyethylene glycols, polyamides, polyurethanes, hydrogels, etc.). A classification of the polymeric systems depending on drug release mechanism like controlled diffusion, hydrolytic and enzymatic degradation, and swelling is presented. Techniques to vary the BAC controlled release time from a few minutes (nanoparticles) to some months (matrices and reservoir devices) and more (implants) are described.
Key words: polymer systems, biologically active compounds, controlled release.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008