ISSN 1995-5537
"Biotechnology" journal Vol. 4, No. 1, 2011
Р. 29-40, Bibliography 78, Russian.
Universal Decimal Classification: 587.26:579.842.1/2
LYSIS OF BACTERIAL CULTURES
AND ITS SIGNIFICANCE FOR BIOTECHNOLOGY
Zabolotny Institute of Microbiology and Virology of National Academy of Sciences of Ukraine, Kyiv
Lysis of industrial bacterial cultures caused by bacteriophages is an actual problem for microbial biotechnology. Its outcome is irreversible and leads to large financial losses. For commercially valuable species of microbes genetically engineering strains resistant against exogenous and endogenous phage lysis are used today. However, nderstanding of molecular genetic basis of nascence, persistence and carry over lytic and lysogenic phage infections at bacterial populations, surely, is useful for biotechnologists and will help them to optimize technological processes and to ensure profitable productions. In thе review the circuits of the most well known lysogenic systems are analyzed, the key concepts concerning lysogeny are provided, and biological feature of «temperate bacteriophagehost bacterium» interaction is explained.
Key words: lysogeny, regulation, moderate phages, protein-repressor, lysogenic conversion.
© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008