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- Category: 3_2015(en)
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ISSN 2410-776X (Online),
ISSN 2410-7751 (Print)
Biotechnologia Acta V. 8, No 3, 2015
https://doi.org/10.15407/biotech8.03.028
Р. 28-44, Bibliography 115, English
Universal Decimal Classification: 579.61/ 571.27
Kyiv Taras Shevchenko National University
Literature data and own author experiments concerning the influence of microbiota on the immune system are summarized. The mechanisms of the diversification of immune response to pathogenic and commensal microorganisms are described. Effect of microorganisms of normal flora on innate and adaptive immunity is characterized. Human inflammatory diseases associated with microbiota disorders are reviewed. Biological properties of probiotic preparations are discussed in context of its modulatory effect on inflammatory response. Prospects of use of immunomodulatory potential of probiotic microorganisms are being analyzed.
Key words: gut microbiota, immunomodulation, immunobiotics, inflammation.
© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv, 2015
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- Details
- Category: 3_2015(en)
- Hits: 631
ISSN 2410-776X (Online),
ISSN 2410-7751 (Print)
Biotechnologia Acta V. 8, No 3, 2015
https://doi.org/10.15407/biotech8.03.009
Р. 9-27, Bibliography 92, English
Universal Decimal Classification: 759.873.088.5:661.185
TECHNOLOGIES OF SYNTHESIS OF ORGANIC SUBSTANCES BY MICROORGANISMS USING WASTE BIODIESEL PRODUCTION
Pirog T. P., Grytsenko N. A., Sofilkanych A. P., Savenko I. V.
National University of Food Technologies, Kyiv, Ukraine
We describe here literature and our experimental data concerning microbial synthesis using waste biodiesel production, mono- and dihydric alcohols (1,3-propanediol, 2,3-butanediol, butanol, ethanol), polyols (mannitol, erythritol, arabitol), organic acids (citric, succinic, lactic, glyceric), polymers and compounds with a complex structure (polysaccharides, polyhydroxyalkanoates, surfactants, cephalosporin, cyanocobalamin). In some mentioned cases recombinant producer strains were used.
It was shown that due to the presence of potential inhibitors in the composition of technical (crude) glycerol (methanol, sodium and potassium salts), the efficiency of synthesis of most microbial products on such a substrate is lower than on the purified glycerol. However, the need of utilization of this toxic waste (storage and processing of crude glycerol is a serious environmental problem due to the high alkalinity and the content of methanol in it), compensates the lower rates of synthesis of the final product. Furthermore, currently considering the volumes of crude glycerol formed during the production of biodiesel, microbial technologies are preferred for its utilization, allowing realizing biosynthesis of practically valuable metabolites in the environment with the highest possible concentration of this waste.
Using of crude glycerol as a substrate will reduce the cost of products of microbial synthesis and increase the profitability of biodiesel production.
Key words: biodiesel, technical (crude) glycerol, products of microbial synthesis.
© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv? 2015
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