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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

 6 2014

"Biotechnologia Acta" v. 7, no 6, 2014
Р. 9-16, Bibliography 32, Ukrainian
Universal Decimal classification: 571.27:004.9
https://doi.org/10.15407/biotech7.06.009

In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS

 O. I. Krynina, D. V. Kolibo, S. V. Komisarenko

Palladian Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv

The comparative analysis of 8 antigens of Mycobacterium tuberculosis (MPT83, MPT63, ESAT-6, CFP10, SodA, leuD, panD and HBHA) in silico to determine T-epitopes that can bind MHC class II molecules coding the most common in Eastern Europe HLA-DRB1 alleles was the goal of the work.

The results show that the most immunogenic proteins are SodA, MPT83, leuD and MPT63, which has the largest number of T-epitopes for the alleles of interest. Accordingly, these antigens or their combinations could be promising candidates for development of new vaccines and diagnostics to form anti-TB immunity in Eastern European region and to determine the state of protection of the population.

Key words: Mycobacterium tuberculosis, T-epitope.

© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2014