Biotechnologia Acta


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ISSN 2410-776X (Online),
ISSN 2410-7751 (Print)

Biotechnologia Acta V. 8, No 3, 2015
Р. 95-103, Bibliography , English
Universal Decimal Classification: 579.864.1:615.331
Babenko L. P.1, Lazarenko L. M.1, Demchenko Z. K.1, Konarbaeva O. A.2, Veccio G. Lo3, Spivak M. Ja.1
1Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
2Auezov South Kazakhstan state University, Shymkent, Republic of Kazakhstan
3Centre of the Studies, Barcelona, Spain
The aim of work was to determine antibacterial activity of Lactobacillus casei ІМV В-7280 probiotic strain on the experimental urogenital tract infection of mice. The influence of intravaginal and/or per of administration of this strain once per day during 7 days on the microflora of vagina, kidneys and intestinal contents of Staphylococcus aureus 8325-4 infected mice was studied. It was established, that in cases of experimental staphylococcal infection of urogenital tract L. Casei IMV B-7280 had effective antagonistic activity against S. aureus 8325-4 and opportunistic bacteria. After L. casei IMV B-7280 introduction into infected mice reduction or complete elimination of S. aureus 8325-4 in vagina, kidneys and intestinal contents in different periods of observation was established. Under the influence of L. casei ІМВ В-7280 the number of coliform bacteria, streptococci and staphylococci in the vagina was normalized, and fungal flora — decreased even in comparison with intact mice.
Normalization of kidneys microflora was also observed. In the intestinal contents of infected mice trea ted with L. casei IMV B-7280 the number of streptococci did not change, staphylococci number decreased, but the number of fungal and coliform flora remained relatively low during the observation period. L. casei IMV B-7280 probiotic strain is promising to create immunobiotics with antibacterial action, which can be used for the prevention and treatment of urogenital infections caused by opportunistic microorganisms.
Key words: antibacterial activity, immunobiotics, Lactobacillus casei, Staphylococcus aureus.
© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2008


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