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Home Archive 2012 № 2 ANTIBACTERIAL AND IMMUNOMODULATING PROPERTIES OF LACTO- AND BIFIDOBACTERIA STRAINS AT EXPERIMENTAL STAPHYLOCOCCAL INFECTION V. V. Mokrozub, L. M. Lazarenko,L. P. Babenko, L. M. Shinkarenko,M. Ya. Spivak
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ISSN 1995-5537

Scientific journal

БІОТЕХНОЛОГІЯ
v. 5, No. 2, 2012

"Biotechnology" journal V. 5, No. 2, 2012
Р. 98-105, Bibliography 23, Ukrainian.
Universal Decimal classification: 573.864.1:615.331

ANTIBACTERIAL AND IMMUNOMODULATING PROPERTIES
OF LACTO- AND BIFIDOBACTERIA STRAINS
AT EXPERIMENTAL STAPHYLOCOCCAL INFECTION

V. V. Mokrozub, L. M. Lazarenko,L. P. Babenko, L. M. Shinkarenko,M. Ya. Spivak

Zabolotny Institute of Microbiology and Virology of National Academy of Sciences of Ukraine, Kyiv

Antibacterial and immunomodulating properties of Lactobacillus delbrueckii subsp. Bulgaricus IMV B-7281, Lactobacillus casei IMV B-7280, Lactobacillus acidophilus B-7279 IMV, Bifidobacterium longum VK1 and Bifidobacterium bifidum VK2 strains were determined at the experimental model of staphylococcal infection of mice. It was established that under the influence of these strains it was significantly reduced the number of Staphylococcusaureus colonies, which were seeded out from kidneys of infected mice. At the same time after introduction by mice with staphylococcal infection of separate probiotic strains of lacto- and bifidobacteria it was observed increasing of the CD4/CD8 immunoregulatory index, and also the number of CD19+ - and CD25+-cells in spleen. Lactobacillus delbrueckii subsp. bulgaricus IMV B-7281, Lactobacillus casei IMV B-7280, Lactobacillus acidophilus B-7279 IMV, Bifidobacterium bifidum VK2 and Bifidobacterium longum VK1 strains found to be perspective for probiotics creation, that could be effective against staphylococcal infection and for the immunity correction.

Key words: immunity, interferon, Lactobacillus, Bifidobacterium, Staphylococcus aureus, mice.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008

 

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Home Archive 2012 № 2 ANTIBACTERIAL AND IMMUNOMODULATING PROPERTIES OF LACTO- AND BIFIDOBACTERIA STRAINS AT EXPERIMENTAL STAPHYLOCOCCAL INFECTION V. V. Mokrozub, L. M. Lazarenko,L. P. Babenko, L. M. Shinkarenko,M. Ya. Spivak

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