Biotechnologia Acta

...

  • Increase font size
  • Default font size
  • Decrease font size
Home Archive 2010 № 6 ESTIMATION OF CYTOTOXICITY DEGREE OF PATHOLOGICAL SERUM COMPONENTS USING CELLULAR TEST-SYSTEM E. M. Klimova, E. V. Lavinskaya, A. I. Bozhkov, T. I. Kordon
Print

ISSN 1995-5537

Scientific journal

БІОТЕХНОЛОГІЯ

Т. 3, № 6, 2010

"Biotechnology" journal Vol. 3, No. 6, 2010
Р. 85-91, Bibliography 13, Ukrainian.
Universal Decimal classification: 577.1

ESTIMATION OF CYTOTOXICITY DEGREE OF PATHOLOGICAL SERUM COMPONENTS USING CELLULAR TEST-SYSTEM

E. M. Klimova, E. V. Lavinskaya, A. I. Bozhkov, T. I. Kordon

National Enterprise «Institute of general and urgent surgery
of Academy of Medical Sciences of Ukraine», Kharkiv;
V. N. Karazin’s Research Institute of Biology, Kharkiv National University, Kharkiv

Screening indication of blood serum cytotoxicity with a test-system based on monocellular algae Dunaliella viridis was carried out. Significant differences of morphological and functional parameters D. viridis, induced by cytotoxic factors of various nature were detected. Patterns of morphological and functional changes of the bioindicator cells in the coordinate system were defined. Coefficients of toxicity for investigated biological liquids are calculated. Maximum degree of cytotoxicity was revealed in blood serum received from the patients suffering from biliary cirrhosis (КЦ = 13,01±01) and myasthenia (КЦ = 11,6±0,76), minimal one (КЦ = 5,65±0,66) was with acute varicothrombosis.

Key words: cellular test-system, cytotoxicity, bioindication, screening, pattern.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008

 

Additional menu

Site search

Site navigation

Home Archive 2010 № 6 ESTIMATION OF CYTOTOXICITY DEGREE OF PATHOLOGICAL SERUM COMPONENTS USING CELLULAR TEST-SYSTEM E. M. Klimova, E. V. Lavinskaya, A. I. Bozhkov, T. I. Kordon

Invitation to cooperation

Dear colleagues, we invite you to publish your articles in our journal.
© Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, 2008.
All rights are reserved. Complete or partial reprint of the journal is possible only with the written permission of the publisher.
E-mail
for information: biotech@biochem.kiev.ua.