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Home Archive 2009 № 1 EFFECT OF NANOPARTICLES OF AMORPHOUS HIGHLY DISPERSED SIO2 ON MORPHOLOGICAL STRUCTURE OF THE RATS’ INNER PARTS M. М. Didenko, V. A. Stezhka
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ISSN 1995-5537

Scientific journal

БІОТЕХНОЛОГІЯ

V. 2, No. 1, 2009

"Biotechnology" journal Vol. 2, No. 1, 2009
Р. 80- 87, Bibliography 16, Russian.
Universal Decimal classification: 546.28+577.115/.15+581.4+615.9:001.5

 

ON MORPHOLOGICAL STRUCTURE OF THE RATS’ INNER PARTS
M. М. Didenko, V. A. Stezhka

State Institution «Institute for Occupational Health of AMS of Ukraine», Kyiv

 

The comparative study on the effect of powders of amorphous highly disperse SiO2 nanoparticles (6–7 nm and 54–55 nm) and the powder of the standard Lyuberets quartz PQ-3 after single intratracheal administration in the dose of 50 mg in 3-month experiment was conducted. Under the experiment following changes were observed: transitory decrease of the relative mass of adrenal glands as a sign of the stress effect; persistent hyperemia in inner organs (lungs, liver, kidneys, myocardium), infiltration of their stroma by histiocytes, leucocytes, lymphocytes and plasma cells and the focus of large granular protein dystrophy. The powders of nanoparticles caused more expressed damage in bronchi mucose and morphological disorders in kydney than the powder of the standard Lyuberets quartz PQ-3. There was concluded, that inhalanion of amorphous highly disperse SiO2 nanoparticles into worker’s organism in production conditions is dangerous to health.

Key words: nanoparticles of SiO2, Lyuberets quartz PQ3, intratracheal administration, inner organs morphology.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2008
 

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Home Archive 2009 № 1 EFFECT OF NANOPARTICLES OF AMORPHOUS HIGHLY DISPERSED SIO2 ON MORPHOLOGICAL STRUCTURE OF THE RATS’ INNER PARTS M. М. Didenko, V. A. Stezhka

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