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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

 4 2013

"Biotechnologia Acta" v. 6, no. 4, 2013
https://doi.org/10.15407/biotech6.04.063
Р. 63-77, Bibliography 34, English
Universal Decimal classification: 577.113.3

SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES

A. Mikhailopulo1, A. I. Miroshnikov2

1Institute of Bioorganic Chemistry of Belarus National Academy of Sciences, Minsk, Belarus
2Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, Moscow, Russia

Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the mechanism of functioning of the ribokinase, phosphopentomutase, and uridine, thymidine and purine nucleoside (PNP) phosphorylases, and the role of different factors (structural, electronic, stereochemical) in the glycoside bond formation, (ii) the modern chemistries of the chemo-enzymatic syntheses of nucleosides, (iii) the transglycosylation reaction using natural and sugar modified nucleosides as donors of carbohydrate residues and heterocyclic bases as acceptors catalyzed by nucleoside phosphorylases (NP).

Key words: nucleosides, bio-mimetic synthesis, chemo-enzymatic synthesis, enzymes of nucleic acid metabolism.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2013