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Home Archive 2020 № 2 AROMATIC HYDROCARBONS OF Arthropodae SPECIES: MECHANISMS OF ACTION ON BIOLOGICAL MEMBRANES AND PERSPECTIVES OF BIOMEDICAL APPLICATION Klyuchko O. M.
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ISSN 2410-7751 (Print)
ISSN 2410-776X (Online)

Biotechnologia Acta V. 13, No 1, 2020
Р. 12-31, Bibliography 136, English
Universal Decimal Classification: 004:591.5:612:616-006
https://doi.org/10.15407/biotech13.02.012

AROMATIC HYDROCARBONS OF Arthropodae SPECIES: MECHANISMS OF ACTION ON BIOLOGICAL MEMBRANES AND PERSPECTIVES OF BIOMEDICAL APPLICATION

Klyuchko O. M.

National Aviation University, Kyiv, Ukraine

The work was aimed to summarize the results describing the mechanisms of interaction of some aromatic hydrocarbons, isolated from Arthropodae, with biological membranes. Neurophysiological properties of the substances obtained from spider venoms, derivatives of phenol and indole with polyamine substituents, were studied by the method of transmembrane electrical currents registration in voltage clamp mode. Their influence was revealed as a result of chemo sensitive ionic currents characteristics changes due to the action of these substances on the membranes of rat hippocampal neurons. All of the studied substances were antagonists of glutamate channel-receptor complexes. Their blocking activity characteristics were examined as follows: caused reversible and irreversible blocking effects, the effects dependence on membrane holding potential, difference of their action on activated and inactivated receptors, kinetics of blocking actions, type of antagonism. Antagonists amphiphilic properties and the role of aromatic groups and polyamine substituents during interaction with the membranes were analyzed. The results of such analysis were accepted as a basis for development of physical model of artificial memory device. Principles of its work were explained as well. The results regarding the influence mechanisms of the studied substances on biological membranes were summarized. Some characteristics and functioning peculiarities of the suggested elements of storage devices were discussed. The properties of the proposed substances-analogues meet a number of requirements for the elements of such nano-devices.

Key words: toxins, receptor antagonists, transmembrane electric currents, Arthropodae, artificial memory,  bioinformatics.

© Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, 2020

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      107. Krishtal O. A., Kiskin N. I., Tsyndrenko A. Ya., Klyuchko E. M. Pharmacological properties of amino acid receptors in isolated hippocampal neurons. Receptors and ion channels. Ed. by Ovchinnikov Y. A., Hucho F. Berlin-New York: Walter de Gruyter. 1987, P. 127–137.

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      110. Gonchar O., Klyuchko E., Seredenko M., Oliynik S. Corrections of prooxidant — antioxidant homeostasis of organism under hypoxia of different genesis by yackton, new pharmacological preparation. Sofia (Bulgaria), Acta Physiol. Pharmacol. Bulg. 2003, V. 27, P. 53–58.

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      113. Klyuchko O. M., Klyuchko Z. F., Lizunova A. G. Development Of Database For Noctuidae Species In Ukraine. 5-th International Conference On the Biology Of Butterflies, Roma. 2007.

      114. Klyuchko Z. F., Klyuchko O. M. Diversity аnd biogeography Of Noctuidae Species In Ukraine. 5-th International Conference On the Biology Of Butterflies, Roma. 2007.

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      116. Beloshitsky P. V., Klyuchko O. M. Contribution of Sirotinin’s school into adaptation medicine. Mater. VIII World Congress of International Society for Adaptive Medicine (ISAM). Moscow (Russia). 2006, P. 158.

      117. Klyuchko O. M., Klyuchko Z. F. Ukrainian Noctuidae Database. Mater. Of XIV SEL Congress. Roma (Italy). 2005, P. 49.

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      119. Beloshitsky P., Klyuchko O., Onopchuck Yu., Onopchuck G. Mathematic model for hypoxic states development for healthy people and ones with ischemic heart disease. High altitude medicine and biology: Mater. ISMM Congress. Beijing (China). 2004, V. 5, P. 251.

      120. Beloshitsky P., Klyuchko O., Kostyuk O., Beloshitsky S. Peculiarities of high mountain factors influence on organism. High altitude medicine and biology: Mater. ISMM Congress. Beijing (China). 2004, V. 5, P. 250.

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      122. Gonchar O., Klyuchko O., Seredenko M., Oliynyk B. Correction of metabolic disorders at hypoxia by new pharmacological preparations. Mater. 3 FEPS Congress. Nice (France). 2003, P. 228.

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      124. Seredenko M., Gonchar O., Klyuchko O., Oliynyk S. Peculiarities of prooxidant — antioxidant balance of organism under hypoxia of different genesis and its corrections by new pharmacological preparations. Acta Physiologica Hungarica. Budapest (Hungary). 2002, 89 (1–3), 292.

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Home Archive 2020 № 2 AROMATIC HYDROCARBONS OF Arthropodae SPECIES: MECHANISMS OF ACTION ON BIOLOGICAL MEMBRANES AND PERSPECTIVES OF BIOMEDICAL APPLICATION Klyuchko O. M.

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